"These creams we tested have
tumorigenic [tumor-causing
capability] activities," said
lead researcher Allan H. Conney,
from the university's Susan
Lehman Cullman Laboratory for
Cancer Research.
But, he
added, "I need to emphasize that
what we have done is only in
mice. We don't know what the
implications are for humans. But
it does raise a red flag that
this is something that should be
considered."
The report is published in
the Aug. 14 issue of the
Journal of Investigative
Dermatology.
For the study, Conney's team
exposed hairless mice to an
extended period of UV radiation,
which induced non-melanoma skin
cancer. After stopping UV
treatment, they applied four
different common brands of skin
moisturizers to the animals'
skin five days a week for 17
weeks.
The researchers found that
mice treated with skin
moisturizers showed an increased
rate of tumor formation. In
addition, there were more tumors
on the animals treated with
moisturizers than on the mice
that were only given UV
radiation.
The moisturizers used were
Dermabase, made by Patrick
Laboratories in Minneapolis;
Dermovan, made by Galderma
Laboratory Inc. of Fort Worth,
Texas; Eucerin Original
Moisturizing Cream, made by
Beiersdorf of Hamburg Germany;
and Vanicream, made by
Pharmaceutical Specialties Inc.,
in Rochester, Minn.
Conney's group identified
several ingredients in the
moisturizers that appear to
enhance tumor growth.
"We took out a couple of
ingredients and made a cream
that turned out to be non-tumorigenic,"
Conney said. The resulting
lotion did not increase cancer
growth in mice exposed to UV
radiation, the researchers
found.
"We really don't know what
ingredients in these creams are
doing that," Conney said. "There
is a need to have the various
companies test their creams to
see whether or not there is a
problem."
Conney thinks that companies
can modify their products to
remove this effect. "I am sure
there are creams on the market
that do not have tumorigenic
activities and some of them may
have anti-tumorigenic activity,"
he said.
Dr. Robin Ashinoff, a
clinical associate professor of
dermatology at New York
University School of Medicine in
New York City, thinks the
findings are interesting but she
said they may not apply to
humans.
Drugs that have been
implicated in growth in animals
in the past do not always have
similar effects in humans,
Ashinoff said.
"Certainly, the issue here is
to protect yourself from that
degree of continuous UVB-induced
priming for skin cancer by
practicing good sun protection
and sunscreen use in the first
place," she added.
"These moisturizing creams
might act as an irritant or a
promoter of skin cancer in mice
skin, but extensive study is
needed before we advise people
that their commonly used
moisturizers can cause skin
cancer," Ashinoff said.