What is IVIG
or Intra Venous Immunoglobulin
Special Google Health
1. What is IVIG or Intravenous
IVIg is a collection of antibodies called IgG or Immuno
is a naturally made antibody by plasma cells in our
body, also known as an immunoglobulin-G is a large
Y-shaped protein used by the immune system to neutralize
foreign objects like viruses and bacteria.
IVIg is formed by taking IgG antibodies from about
20,000 plasma donors and mixing them together.
infusion of IVIg has proven effective in immune
deficiency disorders, including nearly all autoimmune
conditions like CIDP and GBS. The
sooner you treat the patient with IVIg the better the
results. There is a short window of opportunity usually
within the first 18 months after the diagnosis.
Treatment with IVIg within the window period is likely
to halt the progress of the disease. Example is Kawasaki
disease, once IVIg is used full recovery follows.
After being exposed to toxins and poisonous chemicals
including carbon monoxide the body's immune system may
mount a attack on the body. This autoimmune attack can
be halted by any anti-inflammatory treatment
2. How does IVIG work?
IVIg is used in immune deficiency
where the body does not make enough antibodies, IVIG
supplies them. For autoimmune disorders like GBS & CIDP,
there is a abnormal antibody (autoantibody) being formed
which is inactivated by IVIG.
Patients with autoimmune disorders like CIDP also are
deficient in antiidotype antibodies. IVIG supplies them.
Antiidotype antibodies are normal antibodies which are
produced in the absence of any antigen. They are capable
of inactivating many different types of antigens.
3. How long does it take to a IVIG
treatment to have a effect?
After IVIg is infused patients may see a response in 24-
48 hours. Some patients will have to wait 3-4 weeks to
see an effect. In a few no effect may be seen. If 4-5
cycles of IVIg do not show any response then try a
different approach like add intravenous steroids and
Everyone is slightly
different as it depends on how long has the disease
process been going on. The sooner one treats it the
disease the faster the response.
Why is IVIG so expensive?
IVIg is obtained from plasma donors who are paid then
the plasma is sent to a processing centers for
mixing, antibody removal, chemical treatment and
filtration to remove viruses. This is followed by
the products to be freeze dried. All this ends up
for IVIG to be priced at $ 48 to $ 60 a gram (cost price
of IVIg). A single infusion of IVIg may cost about $3000
for a child to $10,000 for adults. For a child the cost
is lower as a small IVIg dose is used. If you have
insurance you will see the cost of infusion may go to
sells IVIG from $65 a gram to $72 a gram.(USA prices
The cost of IVIg in
India & Pakistan $46 a gram, lower prices are found in
China where the manufacturer will see IVIg for $10- a
gram. This price has doubled in the last year. A
pharmacy in Bangladesh Dhaka sells the cheapest IVIg 5
dollars a bottle of Baygam made in Germany. At
cidpusa.org we ordered and tested this IVIg was 100%
authentic. (infusions were done in Dhaka testing in
Lahore). FDA does not allow foreign IVIg into USA.
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