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What is CRP

What is CRP syndrome New research shows that healthy people with high levels of anger, hostility or depression also have high blood levels of C-reactive protein, an indicator of inflammation of the arteries. More and more, heart experts are recognizing that this arterial inflammation is key to the cardiovascular disease process, and this latest study suggests reductions in anger might help reduce heart woes."Anger seems to predict an increased risk of heart disease in initially healthy individuals, and several studies have shown that," said study author Edward Suarez, an associate professor of psychiatry and behavioral sciences at Duke University. However, until now, no one had studied links between anger and inflammation. "This is the first step to link the behavior to this [heart disease] mechanism - one that's garnering a lot of attention" among cardiologists, he said.


The findings appear in the September issue of Psychosomatic Medicine.In the study, Suarez tested C-reactive protein (CRP) blood levels in 121 healthy, nonsmoking men and women between 18 and 65 years of age. On the same day, he also measured each participant's level of anger, hostility and depression using a series of standard psychological tests. He found that - in the absence of heart disease risk factors such as smoking, obesity and high blood pressure - high levels of these negative emotional states "significantly predicted the blood level of CRP." Those who were prone to anger, hostility or depression had two to three times higher CRP levels than their more mellow peers, the researchers said. It's not yet clear why this association exists, but studies are under way to shed light on pathways by which anger or depression might encourage inflammation. In one study, Suarez plans to track patients for two years, to see if hotheaded individuals are any more likely to develop elevated CRP levels over time. Other studies are planned that focus on anger's effect on stress hormones such as noradrenaline and norepinephrine. The latter hormone, in particular, works on a second chemical, nuclear factor-kappa B, "as a kind of 'off/on' switch" for inflammation," Suarez said. "When that switch is turned on, it begins a cascade of events that leads to the promotion or release of inflammatory proteins."There is a increase in Homocysteine in these patients and there is a special diet to lower the homocysteine.In the meantime, people concerned about their heart health might want to just "cool it" when tempers flare.

Change yourself

"It's very important to pay attention to how we can change these behaviors," Suarez said. "I know it isn't easy, though.""It's difficult to change patterns of behavior that are intrinsic to who we are as individuals, so it's not going to be an overnight thing," he added. "But we can start by saying, 'What gets me angry?' and 'If I get angry, do I start to feel depressed and withdrawn from my social network?' " Also, take a stress break. "If a walk around the park can calm you down, do it," Suarez said. C-Reactive Protein (CRP) is a protein found in the blood that indicates "inflammation". It is produced in the liver and during infection, and with some forms of cancer and inflammatory diseases (rheumatoid arthritis, lupus) it can be elevated in a blood test. CRP can also be elevated when there is inflammation in the arteries of the heart and is a "marker" for coronary artery disease.

High sensitivity CRP (hsCRP) is a common test that is done to assess the risk of heart disease, stroke and diabetes. Like high cholesterol, it is not the disease in itself, but high levels (over 3.0) that indicate a higher risk. Scientists don't know if it is a marker or is a cause of heart disease, but we do know that inflammation of the heart blood vessel walls is always present in heart attack victims. Inflammation is the body's defense against injury or infection and unstable plaques in the coronary artery can rupture and the inflammatory cells rush in to repair.

 Even people with low cholesterol can have high CRP indicating inflammation.There have been numerous studies of CRP in large populations of people, and it's role as a risk for heart attack is well established. Some believe it is even a better predictor than high LDL cholesterol.Your blood offers many clues about your heart health. For example, high levels of "bad" cholesterol in your blood can be a sign that you're at increased risk of having a heart attack. And other substances in your blood can help your doctor determine if you have heart failure or are at risk of developing plaques in your arteries (atherosclerosis).