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                                                Tetracyclines and pulmonary inflammation

     

              Many KIDNEY syndromes are autoimmune and easily and permanently treatable please read our e-book for permanent cures.

 
 

Please read the autoimmune E-Book to prevent and treat  autoimmune disorders before they get you. 

Tetracyclines and pulmonary inflammation.

Rempe S,

Carl T. Hayden VA Medical Center, Pheonix

Tetracycline and its derivatives, such as chlortetracycline, oxytetracycline, minocycline, doxycycline, methacycline and lymecycline, are naturally occurring or semi-synthetic polyketide compounds that exhibit a well known broad-spectrum antibacterial activity that interferes with prokaryotic protein synthesis at the ribosome level. In addition to this well known antibacterial activity these compounds also exhibit a variety of additional, less well known properties. Among them are separate and distinct anti-inflammatory properties. Tetracycline and related compounds have been shown to be effective chemotherapeutic agents in a wide variety of chronic inflammatory diseases and conditions. These include periodontitis, rosacea, acne, auto-immune diseases such as rheumatoid arthritis and protection of the central nervous system against trauma and neurodegenerative diseases such as stroke, multiple sclerosis and Parkinson disease. Tetracycline and related compounds appear to be beneficial for treatment of several chronic inflammatory airway diseases. Among them are asthma, bronchiectasis, acute respiratory distress syndrome, chemical induced lung damage and cystic fibrosis. The clinical use of tetracycline-type drugs in treatment of chronic airway inflammation is becoming a topic of intense interest. Recent findings in this area have led to an understanding of the myriad physiological, cellular and molecular mechanisms of the inflammatory response and how this response may be controlled to limit damage to host cells and tissues. This review presents a brief summary of the recent research in the area of tetracycline and its derivatives in control of pulmonary inflammation.

Tetracyclines: nonantibiotic properties and their clinical implications.

Sapadin AN, Fleischmajer R.

Department of Dermatology, Mount Sinai School of Medicine, NYC

Tetracyclines are broad-spectrum antibiotics that act as such at the ribosomal level where they interfere with protein synthesis. They were first widely prescribed by dermatologists in the early 1950s when it was discovered that they were effective as a treatment for acne. More recently, biologic actions affecting inflammation, proteolysis, angiogenesis, apoptosis, metal chelation, ionophoresis, and bone metabolism have been researched. The therapeutic effects of tetracycline and its analogues in various diseases have also been investigated. These include rosacea, bullous dermatoses, neutrophilic diseases, pyoderma gangrenosum, sarcoidosis, aortic aneurysms, cancer metastasis, periodontitis, and autoimmune disorders such as rheumatoid arthritis and scleroderma. We review the nonantibiotic properties of tetracycline and its analogues and their potential for clinical application

Anti-inflammatory activity of tetracyclines

Webster G, Del Rosso JQ.

Department of Dermatology, Jefferson Medical College, 833 Chestnut Street, Philadelphia, PA 19107, USA.

Tetracyclines are known to exhibit multiple significant anti-inflammatory actions. This article describes the mechanisms of this anti-inflammatory activity, such as inhibition of chemotaxis, granuloma formation, and protease. The article also discusses the effectiveness of tetracyclines in treating such diseases as acne vulgaris, rosacea, bullous dermatoses, granulomatous disease, and livedo vasculitis.

PMID: 17430750 [PubMed - indexed for MEDLINE]

Positive side-effects of antibiotic and antimicrobial drugs in therapy

Illig L.

Since about 1950 especially, dermatologists world-wide have been utilizing the positive side-effects, discovered by chance, of all groups of antibiotic and antimicrobial drugs. These drugs are used to treat certain non-microbially induced dermatoses, without any knowledge of the mechanisms involved. A short history is given and the most important drugs and the indications for their use are described. The following drugs are undoubtedly effective and sometimes even the therapy of choice: tetracyclines in acne vulgaris and rosacea (including rosacea keratitis); penicillin G in acrodermatitis atrophicans and cold urticaria; dapsone in dermatitis herpetiformis and - as a powerful adjuvant - in acne vulgaris and rosacea. Before the discovery of the socalled immunodepressive drugs, tetracycline was the only alternative to - or at least a highly effective adjuvant of - cortisone in dermatomyositis and chloroquine in localised and systemic lupus erythematosus. Finally, clioquinole was life-saving in acrodermatitis continua in children until this condition was recently identified as a zinc-deficiency syndrome. Therapeutical mechanisms have been found only in the case of acne, rosacea and dermatitis herpetiformis. In most other diseases the nature of the therapeutical effectiveness of antibiotic and antimicrobial drugs still remains a mystery.

PMID: 162143 [PubMed - indexed for MEDLINE]

1. Foods and pesticides

Problem: Foods sprayed by farmers and in grocery stores are never clear of chemicals.
Solution: Buy organic foods, - at the very least wash with soap water and rinse thoroughly. Can you grow your own? Even if it’s only patio tomatoes and herbs, every bit helps.

2. Food Preservatives

Problem: Chemicals added to make food last longer, or look better for higher sales.
Solution: Buy bakery bread, and ask to be sure they aren’t using additives. Buy organic fresh, frozen or canned foods.

3. Dairy

Problem: These days milk from cows can be laden with antibiotics and their food filled with chemicals and can still be sold for human consumption.
Solution: Buy milk from cows raised naturally, or switch to soya milk for some of your baking, and on cereals. This is easily done by introducing it slowly into your new way of eating.

4. Deodorant

Problem: Some brands contain aluminum, and your skin absorbs it!
Solution: Buy brands without it. Try use baking soda – if it works to absorb odors around the house, it will work for you too – and it’s smooth.

5. Stress

Problem: Living in pain from emotions, abuse, crisis and over working.
Solution: Include a few stress relieving habits in your life. Start with a one to 2 hour weekly ritual. It could be a massage. If you don’t have the time and little money Sue Augustine’s book “Five Minute Retreats for Women” has many simple indulging ideas.

6. Cookware

Problem: Cooking with aluminum cookware means you are ingesting aluminum.
Solution: Use glass, cast iron, stoneware, earthenware, high grade steels for cooking.

7. Smoke or secondhand smoke

Problem: Can’t quit, or surrounded by it.
Solution: This is a biggy. Find help to quit and avoid smoke filled areas. If possible get your workplace to participate in a healthier environment – most employers will want to. Make a rule at your house – NO smoking.

8. Processed foods

Problem: Stripped from processed foods, vitamins and nutrients are essential to keeping your resistance high to diseases.
Solution: Get back to basics, include foods in your diet that aren’t processed as much as possible. Avoid prepared packaged meals and eat plenty of raw vegetables and fruit.

9. Air pollution

Problem: Poor air quality from polluted air, in and out of the house. Know what your furniture is made of or protected with. Some adhesives and protection solvents emit toxins over months in your house.
Solution: Use hepa filter air cleaners, avoid your own pollution contributions – gas powered tools. Take your bike or walk when ever possible

10. Artificial foods

Problem: Saccharin and food coloring are unnatural substances for your body.
Solution: Avoid foods with these ingredients. Find the real thing, that doesn’t use substitutes, or cut it out of your diet.

11. Sun

Problem: Over-exposure or repetitive prolonged sun is extremely toxic to your skin.
Solution: Cover up with sun blocking cream, and find shade.

12. Home cleansers

Problem: Many cleansers include toxins you inhale during use. Have you ever felt sick after cleaning floors, bathrooms, your garage and/or any other household cleansing chores?
Solution: Use vinegar, lemon, or baking soda to clean and avoid chlorine.

Good health can be as simple as removing toxins from your daily routines. Your benefits will increase with the amount of effort you put into the change in your lifestyle.

To learn more about on cancer causing toxins and what your alternatives

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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