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 Information on  Nerve Physiology

         

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                  Nerve Cell Physiology-3

 

 

 

 

please return  to page-1 of nerve physiology  page-2

Between areas of myelin are non-myelinated areas called the nodes of Ranvier. Because fat (myelin) acts as an insulator, membrane coated with myelin will not conduct an impulse. So, in a myelinated neuron, action potentials only occur along the nodes and, therefore, impulses 'jump' over the areas of myelin - going from node to node in a process called saltatory conduction (with the word saltatory meaning 'jumping'):

Because the impulse 'jumps' over areas of myelin, an impulse travels much faster along a myelinated neuron than along a non-myelinated neuron.

 


Types of Neurons - the three main types of neurons are:
 


Multipolar
neuron

Unipolar
neuron

Bipolar neuron

Multipolar neurons are so-named because they have many (multi-) processes that extend from the cell body: lots of dendrites plus a single axon. Functionally, these neurons are either motor (conducting impulses that will cause activity such as the contraction of muscles) or association (conducting impulses and permitting 'communication' between neurons within the central nervous system).

Unipolar neurons have but one process from the cell body. However, that single, very short, process splits into longer processes (a dendrite plus an axon). Unipolar neurons are sensory neurons - conducting impulses into the central nervous system.

Bipolar neurons have two processes - one axon & one dendrite. These neurons are also sensory. For example, biopolar neurons can be found in the retina of the eye.


Neuroglial, or glial, cells - general functions include:

    1 - forming myelin sheaths
    2 - protecting neurons (via phagocytosis)
    3 - regulating the internal environment of neurons
    in the central nervous system
Synapse = point of impulse transmission between neurons; impulses are transmitted from pre-synaptic neurons to post-synaptic neurons

Synapses usually occur between the axon of a pre-synaptic neuron & a dendrite or cell body of a post-synaptic neuron. At a synapse, the end of the axon is 'swollen' and referred to as an end bulb or synaptic knob. Within the end bulb are found lots of synaptic vesicles (which contain neurotransmitter chemicals) and mitochondria (which provide ATP to make more neurotransmitter). Between the end bulb and the dendrite (or cell body) of the post-synaptic neuron, there is a gap commonly referred to as the synaptic cleft. So, pre- and post-synaptic membranes do not actually come in contact. That means that the impulse cannot be transmitted directly. Rather, the impulse is transmitted by the release of chemicals called chemical transmitters (or neurotransmitters).



 

When an impulse arrives at the end bulb, the end bulb membrane becomes more permeable to calcium. Calcium diffuses into the end bulb & activates enzymes that cause the synaptic vesicles to move toward the synaptic cleft. Some vesicles fuse with the membrane and release their neurotransmitter (a good example of exocytosis). The neurotransmitter molecules diffuse across the cleft and fit into receptor sites in the postsynaptic membrane. When these sites are filled, sodium channels (also called, as in the figure above, chemically gated ion channels) open & permit an inward diffusion of sodium ions. This, of course, causes the membrane potential to become less negative (or, in other words, to approach the threshold potential). If enough neurotransmitter is released, and enough sodium channels are opened, then the membrane potential will reach threshold. If so, an action potential occurs and spreads along the membrane of the post-synaptic neuron (in other words, the impulse will be transmitted). Of course, if insufficient neurotransmitter is released, the impulse will not be transmitted.


Source: http://www.franklincoll.edu/bioweb/bio120/week2.htm

This describes what happens when an 'excitatory' neurotransmitter is released at a synapse. However, not all neurotransmitters are 'excitatory':
 

Types of neurotransmitters:

    1- Excitatory - neurotransmitters that make membrane potential less negative (via increased permeability of the membrane to sodium) &, therefore, tend to 'excite' or stimulate the postsynaptic membrane

    2 - Inhibitory - neurotransmitters that make membrane potential more negative (via increased permeability of the membrane to potassium) &, therefore, tend to 'inhibit' (or make less likely) the transmission of an impulse. One example of an inhibitory neurotransmitter is gamma aminobutyric acid (GABA; shown below). Medically, GABA has been used to treat both epilepsy and hypertension. Another example of an inhibitory neurotransmitter is beta-endorphin, which results in decreased pain perception by the CNS.
     

Please continue to next page



Used by permission of John W. Kimball

Summation:

    1 - Temporal summation - transmission of an impulse by rapid stimulation of one or more pre-synaptic neurons

    2 - Spatial summation - transmission of an impulse by simultaneous or nearly simultaneous stimulation of two or more pre-synaptic neurons
     


Used by permission of John W. Kimball
Resources National Institutes of Health (NIH) Resources

 

 

Nerves    Click to view different size nerve fibers.

 

 

 

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