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                                   Pulsed Magnetic Fields

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Magnet therapy has a long history in traditional folk medicine. Reliable documentation tells us that Chinese doctors believed in the therapeutic value of magnets at least 2,000 years ago, and probably earlier than that. In sixteenth century Europe, Paracelsus used magnets to treat a variety of ailments. Two centuries later, Mesmer became famous for treating various disorders with magnets.

In the middle decades of the twentieth century, scientists in various parts of the world began performing studies on the therapeutic use of magnets. From the 1940s on, magnets became increasingly popular in Japan. Yoshio Manaka, one of the influential Japanese acupuncturists of the twentieth century, used magnets in conjunction with acupuncture. Magnet therapy also became a commonly used technique of self-administered medicine in Japan. For example, a type of plaster containing a small magnet became popular for treating aches and pains, especially among the elderly. Magnetic mattress pads, bracelets, and necklaces also became popular—again, mainly among the elderly. During the 1970s, both magnets and electromagnetic machines became popular among athletes in many countries for treating sports-related injuries.

Types of Magnet Therapy and Their Uses

The term magnet therapy usually refers to the use of static magnets placed directly on the body, generally over regions of pain. Static magnets are either attached to the body by tape or encapsulated in specially designed products such as belts, wraps, or mattress pads. Static magnets are also sometimes known as permanent magnets.

Static magnets come in various strengths. The units of measuring magnet strength are gauss and tesla. One tesla equals 10,000 gauss. A refrigerator magnet, for example, is around 200 gauss. Therapeutic magnets measure anywhere from 200 to 10,000 gauss, but the most commonly used measure 400 to 800 gauss.

Pulsed Electromagnetic Field Therapy (PEMF)

Pulsed electromagnetic field therapy (PEMF) is quite distinct from magnet therapy itself. (The term “electromagnetic field” does not, in this case, refer to magnetism in the ordinary sense.) Nonetheless, for historical reasons, it is often classified together with true magnetic therapies. Because of that, we discuss it here.

Bone has a remarkable capacity to heal from injury. In some cases, though, the broken ends do not join, called non-union fractures. PEMF therapy has been used to stimulate bone repair in non-union and other fractures since the 1970s; this is a relatively accepted use and will not be discussed here. More controversially, PEMF has shown promise for osteoarthritis, stress incontinence, and possibly other conditions as well.

Osteoarthritis

Three double-blind, placebo-controlled studies enrolling a total of more than 350 people suggest that pulsed electromagnetic field therapy can improve symptoms of

For example, a double-blind, placebo-controlled study tested PEMF in 86 people with osteoarthritis of the knee and 81 with osteoarthritis of the cervical spine. Participants received 18 half-hour sessions with either a PEMF machine or a sham device. The treated participants showed significantly greater improvements in disease severity than those given placebo. For both osteoarthritis conditions, benefits lasted for at least 1 month after treatment was stopped.

A more recent double-blind trial evaluated low-power, extremely low-frequency pulsed electromagnetic fields for the treatment of knee osteoarthritis.  A total of 176 people received eight sessions of either sham or real treatment over a period of 2 weeks. The results showed significantly greater pain reduction in the treated group.

Stress Incontinence

Many women experience stress incontinence, the leakage of urine following any action that puts pressure on the bladder. Laughter, physical exercise, and coughing can all trigger this unpleasant occurrence. A recent study suggests that PEMF treatment might be helpful. In this placebo-controlled study, researchers applied high-intensity pulsating magnetic fields to 62 women with stress incontinence.14  The intention was to stimulate the nerves that control the pelvic muscles.

The results showed that one session of magnetic stimulation significantly reduced episodes of urinary leakage over the following week, compared to placebo. In the treated group, 74% experienced significant improvement, compared to only 32% in the placebo group. Presumably, the high-intensity magnetic field used in this treatment created electrical currents in the pelvic muscles and nerves. This was confirmed by objective examination of 13 patients, which found that magnetic stimulation was in fact increasing the strength of closure at the exit from the bladder. However, there was one serious flaw in this study: it does not appear to have been double-blind. (For more information on why this is important, see Why Does This Database Rely on Double-blind Studies?) Researchers apparently knew which participants were getting real treatment and which were not, and therefore might have unconsciously biased their observations to conform to their expectations. Thus, the promise of electromagnetic therapy for stress incontinence still needs to be validated in properly designed trials.

Multiple Sclerosis

A 2-month, double-blind, placebo-controlled study of 30 people with multiple sclerosis was conducted using a PEMF device.13  Participants were instructed to tape the device to one of three different acupuncture points on the shoulder, back, or hip. The study found statistically significant improvements in the treatment group, most notably in bladder control, hand function, and muscle spasticity. Benefits were seen in another small study too.58 

Erectile Dysfunction

In a 3-week, double-blind, placebo-controlled trial, 20 men with erectile dysfunction received PEMF therapy or placebo.30  The magnetic therapy was administered by means of a small box worn near the genital area and kept in place as continuously as possible over the study period; neither participants nor observers knew whether the device was actually activated or not. The results showed that use of PEMF significantly improved sexual function compared to placebo.

Migraines

In a double-blind trial, 42 people with migraine headaches were given treatment with real or placebo pulsed electromagnetic therapy to the inner thighs for 1 hour, 5 times per week for 2 weeks.  The results showed benefits in headache frequency and severity. However, the study design was rather convoluted and nonstandard, and, therefore, the results are difficult to interpret.

Electromagnetic Therapy: Repetitive Transcranial Magnetic Stimulation

Unlike PEMF, repetitive transcranial magnetic stimulation (rTMS) does in fact involve magnetic fields, and is, therefore, more closely related to standard magnet therapy. It involves applying low-frequency magnetic pulses to the brain. rTMS has been investigated for treating emotional illnesses and other conditions that originate in the brain. The results of preliminary studies have been generally promising.

Depression

About 20 small studies have evaluated rTMS for the treatment of depression (including severe depression that does not respond to standard treatment, as well as the depressive phase of bipolar illness), and most found it effective.

In one of the best of these studies, 70 people with major depression were given rTMS or sham rTMS in a double-blind setting over a period of 2 weeks  The results showed that participants who had received actual treatment experienced significantly greater improvement than did those receiving sham treatment.

In another trial involving 92 older patients whose depression had been linked to poor blood flow to the brain (so-called vascular depression), actual rTMS was significantly more effective than sham rTMS. Benefits were more notable in younger patients.

Two separate studies suggest that rTMS may be an effective additional treatment for the 20%-30% of depressed people for whom conventional drug therapy is not successful.  ECT (electroconvulsive therapy, or shock treatment) is often used for people who fall in this category, but rTMS may be an equally effective and less traumatic alternative. 

Epilepsy

In a double-blind, placebo-controlled trial, 24 people with epilepsy (technically, partial complex seizures or secondarily generalized seizures) not fully responsive to drug treatment were given treatment with rTMS or sham rTMS twice daily for a week.The results showed a mild reduction in seizures among the people given real rTMS. However, the benefits rapidly disappeared when treatment was stopped. Similarly short-lived effects were seen in an open trial.

Schizophrenia

A double-blind, placebo-controlled crossover trial looked at the use of low-frequency rTMS in 12 people diagnosed with schizophrenia and manifesting frequent and treatment-resistant auditory hallucinations (hearing voices).  Participants received rTMS for 4 days, with length of treatment building from 4 minutes on the first day to 16 minutes on the fourth day. Active stimulation significantly reduced the incidence of auditory hallucinations compared to sham stimulation. The extent of the benefit varied widely, lasting from 1 day in one participant to 2 months in another. Possible benefits were seen in other small studies as well.

Parkinson's Disease

A 2-month, double-blind, placebo-controlled trial of 18 people with Parkinson’s disease compared rTMS against placebo. The results suggest that rTMS therapy can improve Parkinson’s symptoms.  Benefits were seen in two other small studies too. 

Myofascial Pain Syndrome

Myofascial pain syndrome is a condition similar to fibromyalgia but more localized; while fibromyalgia involves tender trigger points all over the body, myofascial pain syndrome involves trigger points clustered in one portion of the body only. One controlled trial found indications that a form of rTMS applied to the painful area (rather than to the brain) may be effective for myofascial pain syndrome of the trapezius muscle.

Surgery Support (Reducing Pain)

One study of 165 people failed to find that use of static magnets over the surgical incision reduced post surgical pain.

Tinnitus

One preliminary study found indications that rTMS may be helpful for (ringing in the ear).

Post-traumatic Stress Disorder

A small, double-blind, placebo-controlled study found that use of rTMS may be able to reduce symptoms of post-traumatic stress disorder.

Cigarette Addiction

A very small, double-blind, placebo-controlled study found evidence that rTMS may reduce craving for cigarettes in people attempting to give up smokeing Myotropic Lateral Sclerosis (Lou Gerhig’s Disease)

Amyotrophic lateral sclerosis (ALS) is a nerve disorder that causes progressive muscle weakness. A small pilot study hinted that rTMS may be beneficial at least temporarily.

 

References

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2. Vallbona C, Hazlewood CF, Jurida G. Response of pain to static magnetic fields in postpolio patients: a double blind pilot study. Arch Phys Med Rehabil. 1997;78:1200-1203.

3. Colbert AP, Markov MS, Banerji M, et al. Magnetic mattress pad use in patients with fibromyalgia: a randomized double-blind pilot study. J Back Musculoskeletal Rehabilitation. 1999;13:19-31.

4. Weintraub M. Magnetic bio-stimulation in painful diabetic peripheral neuropathy: a novel intervention-a randomized, double-placebo crossover study. Am J Pain Manag. 1999;9:8-17.

5. Man D, Man B, Plosker H. The influence of permanent magnetic field therapy on wound healing in suction lipectomy patients: A double-blind study. Plast Reconstr Surg. 1999;104:2261-2266.

6. Collacot EA, Zimmerman JT, White DW, et al. Bipolar permanent magnets for the treatment of chronic low back pain: a pilot study. JAMA. 2000;283:1322-1325.

7. Brown CS, Parker N, Ling F, et al. Effect of magnets on chronic pelvic pain. Obstet Gynecol. 2000;95:S29.

8. Theodore WH, Hunter K, Chen R, et al. Transcranial magnetic stimulation for the treatment of seizures: A controlled study. Neurology. 2002;59:560-562.

9. Hinman MR, Ford J, Heyl H. Effects of static magnets on chronic knee pain and physical function: a double-blind study. Altern Ther Health Med. 2002;8:50-55.

10. Engstrom S, Markov MS, McLean MJ, et al. Effects of non-uniform static magnetic fields on the rate of myosin phosphorylation. Bioelectromagnetics. 2002;23:475-479.

11. Trock DH, Bollet AJ, Dyer RH Jr, et al. A double-blind trial of the clinical effects of pulsed electromagnetic fields in osteoarthritis. J Rheumatol. 1993;20:456-460.

12. Trock DH, Bollet AJ, Markoll R. The effect of pulsed electromagnetic fields in the treatment of osteoarthritis of the knee and cervical spine. Report of randomized, double blind, placebo controlled trials. J Rheumatol. 1994;21:1903-1911.

13. Richards TL, Lappin MS, Acosta-Urquidi J, et al. Double-blind study of pulsing magnetic field effects on multiple sclerosis. J Altern Complement Med. 1997;3:21-29.

14. Fujishiro T, Enomoto H, Ugawa Y, et al. Magnetic stimulation of the sacral roots for the treatment of stress incontinence: an investigational study and placebo controlled trial. J Urol. 2000;164:1277-1279.

15. Sherman RA, Acosta NM, Robson L. Treatment of migraine with pulsing electromagnetic fields: a double-blind, placebo-controlled study. Headache. 1999;39:567-575.

16. Pascual-Leone A, Rubio B, Pallardo F, et al. Rapid-rate transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in drug-resistant depression. Lancet. 1996;348:233-237.

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18. George MS, Wassermann EM, Kimbrell TA, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial. Am J Psychiatry. 1997;154:1752-1756.

19. Garcia-Toro M, Mayol A, Arnillas H, et al. Modest adjunctive benefit with transcranial magnetic stimulation in medication-resistant depression. J Affect Disord. 2001;64:271-275.

20. Szuba MP, O'Reardon JP, Rai AS, et al. Acute mood and thyroid stimulating hormone effects of transcranial magnetic stimulation in major depression. Biol Psychiatry. 2001;50:22-27.

21. Teneback CC, Nahas Z, Speer AM, et al. Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J Neuropsychiatry Clin Neurosci. 1999;11:426-435.

22. Grunhaus L, Dannon PN, Schreiber S, et al. Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study. Biol Psychiatry. 2000;47:314-324.

23. Kirkcaldie MT, Pridmore SA, Pascual-Leone A. Transcranial magnetic stimulation as therapy for depression and other disorders. Aust N Z J Psychiatry. 1997;31:264-272.

24. Pridmore S. Substitution of rapid transcranial magnetic stimulation treatments for electroconvulsive therapy treatments in a course of electroconvulsive therapy. Depress Anxiety. 2000;12:118-123.

25. Berman RM, Narasimhan M, Sanacora, et al. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression. Biol Psychiatry. 2000;47:332-337.

26. Tergau F, Naumann U, Paulus W, et al. Low-frequency repetitive transcranial magnetic stimulation improves intractable epilepsy. Lancet. 1999;353:2209.

27. Hoffman RE, Boutros NN, Hu S, et al. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet. 2000;355:1073-1075.

28. Rollnik JD, Huber TJ, Mogk H, et al. High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients. Neuroreport. 2000;11:4013-4015.

29. Alonso P, Pujol J, Cardoner N, et al. Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a double-blind, placebo-controlled study. Am J Psychiatry. 2001;158:1143-1145.

30. Pelka RB, Jaenicke C, Gruenwald J. Impulse magnetic-field therapy for erectile dysfunction: a double-blind, placebo-controlled study. Adv Ther. 2002;19:53-60.

31. Colbert AP, Markov MS, Banerji M, et al. Magnetic mattress pad use in patients with fibromyalgia: a randomized double-blind pilot study. J Back Musculoskeletal Rehabilitation. 1999;13:19-31.

32. Loo C, Sachdev P, Elsayed H, et al. Effects of a 2- to 4-week course of repetitive transcranial magnetic stimulation (rTMS) on neuropsychologic functioning, electroencephalogram, and auditory threshold in depressed patients. Biol Psychiatry. 2001;49:615-623.

33. Van Lake P, Mattioni T. The effect of therapeutic magnet on implantable pacemaker and defibrilattor devices [abstract]. Pacing Clin Electrophysiol. 2000;23:723.

34. Weinberger A, Nyska A, Giler S. Treatment of experimental inflammatory synovitis with continuous magnetic field. Isr J Med Sci. 1996;32:1197-1201.

35. Segal NA, Toda Y, Huston J, et al. Two configurations of static magnetic fields for treating rheumatoid arthritis of the knee: double-blind clinical trial. Arch Phys Med Rehabil. 2001;82:1453-1460.

36. Alfano AP, Taylor AG, Foresman PA, et al. Static magnetic fields for treatment of fibromyalgia: a randomized controlled trial. J Altern Complement Med. 2001;7:53-64.

37. Holcomb RR, Parker RA, Harrison MS. Biomagnetics in the treatment of human pain: past, present, future. Environ Med. 1991;8:24-30.

38. Jacobson JI, Gorman R, Yamanashi WS, et al. Low-amplitude, extremely low frequency magnetic fields for the treatment of osteoarthritic knees: a double-blind clinical study. Altern Ther Health Med. 2001;7:54-60,62-64,66-69.

39. Hasey G. Transcranial magnetic stimulation in the treatment of mood disorder: a review and comparison with electroconvulsive therapy. Can J Psychiatry. 2001;46:720-727.

40. Shimamoto H, Takasaki K, Shigemori M, et al. Therapeutic effect and mechanism of repetitive transcranial magnetic stimulation in Parkinson's disease. J Neurol. 2001;248(suppl 3):III/48-III/52.

41. Manes F, Jorge R, Morcuende M, et al. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. Int Psychogeriatr. 2001;13:225-231.

42. Carter R, Hall T, Aspy CB, et al. Effectiveness of magnet therapy for treatment of wrist pain attributed to carpal tunnel syndrome. J Fam Pract. 2002;51:38-40.

43. Gmitrov J, Ohkubo C, Okano H. Effect of 0.25 T static magnetic field on microcirculation in rabbits. Bioelectromagnetics. 2002;23:224-229.

44. Martel GF, Andrews SC, Roseboom CG. Comparison of static and placebo magnets on resting forearm blood flow in young, healthy men. J Orthop Sports Phys Ther. 2002;32:518-524.

45. Hong CZ, Lin JC, Bender LF, et al. Magnetic necklace: its therapeutic effectiveness on neck and shoulder pain. Arch Phys Med Rehabil. 1982;63:462-466.

46. Brown CS, Ling FW, Wan JY, et al. Efficacy of static magnetic field therapy in chronic pelvic pain: A double-blind pilot study. Am J Obstet Gynecol. 2002;187:1581-1587.

47. Nicolakis P, Kollmitzer J, Crevenna R, et al. Pulsed magnetic field therapy for osteoarthritis of the knee—a double-blind sham-controlled trial. Wien Klin Wochenschr. 2002;114:678-684.

48. Dolberg OT, Dannon PN, Schreiber S, et al. Transcranial magnetic stimulation in patients with bipolar depression: a double blind, controlled study. Bipolar Disord. 2002;4:94 95.

49. Janicak PG, Dowd SM, Martis B, et al. Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trial. Biol Psychiatry. 2002;51:659-667.

50. Boutros NN, Gueorguieva R, Hoffman RE, et al. Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression. Psychiatry Res. 2002;113:245-254.

51. Mayrovitz HN, Groseclose EE, Markov M, et al. Effects of permanent magnets on resting skin blood perfusion in healthy persons assessed by laser Doppler flowmetry and imaging. Bioelectromagnetics. 2001;22:494-502.

52. Wolsko PM, Eisenberg DM, Simon LS, et al. Double-blind placebo-controlled trial of static magnets for the treatment of osteoarthritis of the knee: results of a pilot study. Altern Ther Health Med. 2004;10:36-43.

53. Weintraub MI, Wolfe GI, Barohn RA, et al. Static magnetic field therapy for symptomatic diabetic neuropathy: a randomized, double-blind, placebo-controlled trial. Arch Phys Med Rehabil. 2003;84:736-746.

54. Winemiller MH, Billow RG, Laskowski ER, et al. Effect of magnetic vs sham-magnetic insoles on plantar heel pain. A randomized controlled trial. JAMA. 2003;290:1474-1478.

55. Harlow T, Greaves C, White A, et al. Randomised controlled trial of magnetic bracelets for relieving pain in osteoarthritis of the hip and knee. BMJ. 2004;329:1450-1454.

56. Reeser JC, Smith DT, Fischer V, et al. Static magnetic fields neither prevent nor diminish symptoms and signs of delayed onset muscle soreness. Arch Phys Med Rehabil. 2005;86:565-570.

57. Schall DM, Ishee JH, Titlow LW. Effect of magnetic therapy on selected physical performances. J Strength Cond Res. 2003;17:299-302.

58. Lappin MS, Lawrie FW, Richards TL, et al. Effects of a pulsed electromagnetic therapy on multiple sclerosis fatigue and quality of life: a double-blind, placebo controlled trial. Altern Ther Health Med. 2003;9:38-48.

59. Kauffmann CD, Cheema MA, Miller BE. Slow right prefrontal transcranial magnetic stimulation as a treatment for medication-resistant depression: a double-blind, placebo-controlled study. Depress Anxiety. 2004;19:59-62.

60. Fitzgerald PB, Brown TL, Marston NA, et al. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2003;60:1002-1008.

61. Kosel M, Frick C, Lisanby SH, et al. Magnetic seizure therapy improves mood in refractory major depression. Neuropsychopharmacology. 2003 Aug 27. [Epub ahead of print]

62. Herwig U, Lampe Y, Juengling FD, et al. Add-on rTMS for treatment of depression: a pilot study using stereotaxic coil-navigation according to PET data. J Psychiatr Res. 2003;37:267-275.

63. Holi MM, Eronen M, Toivonen K, et al. Left prefrontal repetitive transcranial magnetic stimulation in schizophrenia. Schizophr Bull. 2004;30:429-434.

64. Khedr EM, Farweez HM, Islam H. Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson's disease patients. Eur J Neurol. 2003;10:567-572.

65. Smania N, Corato E, Fiaschi A, et al. Repetitive magnetic stimulation: a novel therapeutic approach for myofascial pain syndrome. J Neurol. 2005 Feb 23. [Epub ahead of print]

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67. Cohen H, Kaplan Z, Kotler M, et al. Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study. Am J Psychiatry. 2004;161:515-524.

68. Eichhammer P, Johann M, Kharraz A, et al. High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking. J Clin Psychiatry. 2003;64:951-953.

69. Eccles NK. A randomized, double-blinded, placebo-controlled pilot study to investigate the effectiveness of a static magnet to relieve dysmenorrhea. J Altern Complement Med. 2005;11:681-687.

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74. Garland D, Holt P, Harrington JT, et al. A 3-month, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a highly optimized, capacitively coupled, pulsed electrical stimulator in patients with osteoarthritis of the knee. Osteoarthritis Cartilage. 2007 Feb 13. [Epub ahead of print]

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77. Janicak PG, O'Reardon JP, Sampson SM, et al. Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment. J Clin Psychiatry. 2008 Jan 23.

78. Zanette G, Forgione A, Manganotti P, et al. The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis. J Neurol Sci. 2008 Feb 26.

79. Jorge RE, Moser DJ, Acion L, et al. Treatment of vascular depression using repetitive transcranial magnetic stimulation. Arch Gen Psychiatry. 2008;65:268-276.

80. Bretlau LG, Lunde M, Lindberg L, et al. Repetitive transcranial magnetic stimulation (rTMS) in combination with escitalopram in patients with treatment-resistant major depression. A double-blind, randomised, sham-controlled trial. Pharmacopsychiatry. 2008;41:41-47.


Modified from Alternative therapies

 

 

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