Oophoritis is an autoimmune disease.

Oophoritis is an autoimmune disease. Autoimmune oophoritis is characterized by lymphocytic infiltration.

Definition: Autoimmune oophoritis is a disease of women caused by autoimmune inflammation of ovaries resulting in their destruction, atrophy, and fibrosis with a loss of fertility and ovary hormonal production.

Description: Autoimmune oophoritis is a causes premature ovarian failure (POF) in 10 percent of cases. Women with POF have premature menopause before 40 years of age (secondary amenorrhea). They stop menstruating, they are infertile, and they have deficient estrogen and progesterone. There is a clear association between serum adrenal cortex autoantibodies and the presence of histologically confirmed autoimmune oophoritis.

Symptoms:

Primary amenorrhea (menstruation has never occurred),
secondary amenorrhea (menstruation appeared at puberty but subsequently stopped),
infertility, and
sex hormone deficiency

Diagnosis: StCA autoantibodies or antibodies are good predictive markers for future gonadal failure. In studies, ovarian laparoscopy biopsy is provided, but it is not routine since no treatment is available.

Treatment: No immunosuppressive has been proven safe and effective by prospective randomized placebo-controlled study. There are few reports on a successful ovulation-inducing treatment with high dosages of corticosteroids. However because of risks, long term prednisone treatment is not routinely used. Hormone replacement therapy is used, but it can not return fertility.

Pathogenesis: Oophoritis is an autoimmune disease. Autoimmune oophoritis is characterized by lymphocytic infiltration.

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