by Frederich
R. Klenner,
BS, MS, MD
Journal of
Applied
Nutrition,
1973
Recommended
Treatment
Schedule
Our
treatment
schedule:
1) Thiamin
hydrochloride:
300mg to
500mg, 30
minutes
before meals
and bed
hour, and
during the
night if
awake. The
higher
amounts in
long-standing
cases. This
requirement
is high,
since much
is lost
through
action of
gastric
juices and
loss due to
perspiration.
400 mg.
daily by
needle,
given
intramuscularly.
During
summer
months this
can be given
every 12
hours to
good
advantage.
Two to three
times each
week, and
where office
access is
convenient,
20 mg. per
kg. body
weight, or
at least
1000 mg. is
administered
intravenously.
This is
given with
100 mg to
200 mg.
Niacine
(nicotinic
acid) which
is available
100 mg. in
10cc ampules.
(The
concentrated
Niacin,
available in
30cc vials,
must be
diluted if
employed
intravenously.)
The
intravenous
dose is
given with
the patient
in a
recumbent
position. A
20cc to 30cc
syringe,
carrying a
one-inch
22-guage
needle
should be
employed.
The
injection is
given slowly
(5 to 7
minutes)
holding the
syringe with
one hand.
The
usually-employed
three
fingers of
the other
hand must be
on the
patient’s
pulse. An
increased
pulse rate
indicates
too fast a
flow of the
medicine.
This
indicates
the rate of
phosphorylization.
Thiamin
hydrochloride
is, indeed,
a toxic
substance,
and
anaphylactic
reactions
have been
reported,
but I have
never seen a
case in
treating
thousands of
patients,
(not
necessarily
Myasthenia
Gravis or
Multiple
Sclerosis),
in 30 years
of clinical
observation.
I have
observed one
case of
extreme
sensitivity
in which
itching was
present
within One
minute after
an
intramuscular
injection of
100mg. This
was
immediately
controlled
with 5cc
Benedryl,
I.M. It must
be
remembered
that once
thiamin
hydrochloride
is
phosphorylated,
it is no
longer a
critical
allergic
substance,
but is
cocarboxylase,
a necessary
but
absolutely
harmless
agent. (My
problem has
been the
preservatives
now required
by FDA
regulations,
and they
should be
removed.)
Higher doses
of thiamin
can be used,
but then the
dilution
factor must
be greater.
2) Niacin
(nicotinic
acid): We
recommend
100mg to 3
grams,
thirty
minutes
before meals
and at bed
hour, and
also during
the night if
awake –
whichever
dose will
produce a
strong body
flush.
Niacin
dilates the
blood
vessels,
even those
that have
been
compressed
by scar
tissue,
allowing a
greater
amount of
nutrient
material to
reach the
cell
laboratory
or factor
comprising
muscles and
nerves. This
constant,
repeated
dilatation
of the blood
vessels acts
in the same
manner as
the dilating
urethral
catheter to
correct
constriction.
One is
chemical,
the other is
mechanical.
Hot fluids
taken at the
same time as
the niacin
will enhance
the flush.
Pyridoxine
has been a
suggested
stimulant.
The lack of
constant
flushing in
Multiple
Sclerosis is
disappointing
but not
hopeless. It
will require
a longer
time to
achieve
results.
Many timed
patients
will flush
with
intramuscular
niacin when
they fail to
flush by the
oral route.
An
occasional
patient will
experience
thr
sensation of
a chill
following
nicotinic
acid flush.
This is
transient
and of no
consequence.
Food, even
jelly beans
or a glass
of milk,
will prevent
or minimize
the
experience.
Some
patients
will flush
sometimes
and not at
other times,
even during
a single
day. if no
flush
develops
within 45
minutes, the
dose should
be repeated.
A delayed
reaction of
several
hours can
occur, and
should this
be
superimposed
upon a
previous
medication,
the result
could be
severe. Do
not scratch
when itching
from niacin.
Just press
the area
with your
fingers, or
better
still, with
a cube of
ice.
Antihistamines
will stop
the itching
and limit
the flush,
should this
be
necessary.
Niacin
should be
given very
slowly by
the
intravenous
route in the
geriatric
patient,
with or
without
cardiac
pathology,
since it can
produce
dilatation
great enough
to effect
right-side
heart
failure.
Myasthenia
Gravis
patients
sometimes
attain
geriatric
status.
Vasomotor
collapse of
peripheral
vessels,
although
rare, can
occur. Light
mg. ecadron
given I.M.
will reverse
this
condition.
3)
Pyridoxine
(Vitamin
B6): Lack of
this vitamin
has been
shown to
induce
microcytic
hypochromic
anemia and
neurologic
lesions in
dogs and
pigs. The
term B6
includes not
only
pyridoxine,
but also
pyridoxal
and
pyridoxamine,
all three
compounds
being found
in nature.
These
derivatives
have
biological
activity
equal to
that of
pyridoxine,
as
demonstrated
in rats.
Pyridoxine
plays a part
in the
metabolism
of
unsaturated
fatty acids.
It is also
important in
the
metabolism
of amino
acids.
Pyridoxal
phosphate
functions as
a coenzyme,
and in
transamination
reactions.
100mg to
200mg is
given before
meals and
bed hour. At
least 100mg
daily is
given
intramuscularly.
4) Cobalamin
(Vitamin
B12): It is
thought that
vitamin B12
acts as a
catalyst in
the
formation of
the purine
and
pyrimidine
deoxyribosides
which are
present in
deoxyribonucleic
acid.
Technically,
B12 is
cyanocobalamin.
vitamin B12
with
pterylglutamic
reduces the
requirement
for choline
essential in
the
treatment of
neurological
diseases.
1000mcg. is
given three
times each
week by
needle
(repository
type). The
incident of
dermatitis
from
continued
use of
vitamin B12
by needle is
roughly 15%.
I have never
seen this
develop in a
patient with
Myasthenia
Gravis or
Multiple
Sclerosis.
B12 is
recognized
as a factor
in the
synthesis of
Myelin.
5) Ascorbic
Acid
(Vitamin C):
The use of
high daily
doses of
vitamin C
will prevent
a
superimposed
illness and
will lend
itself in
metabolism.
Ten to
twenty grams
should be
taken daily
by mouth in
divided
doses.
6)
Riboflavin
(Vitamin
B2): A
deficiency
of vitamin
B2 in young
animals
results in
inhibition
of growth
terminated
by death.
The yellow
enzyme can,
as
demonstrated
by Warburg
and
Christian,
participate
in a series
of enzyme
reactions
involved in
the
metabolism
of
carbohydrates.
It is
capable of
transporting
hydrogen
from reduced
coenzyme II,
a niacin
coenzyme
which
attacks
hexosemonophosphate,
regenerating
the
riboflavin
phosphate-protein
complex.
Riboflavin
also take
part in
enzymic
reactions as
a
dinucleotids
prosthetic
group,
consisting
of
riboflavin,
two
phosphoric
acids, riboe
and adenine.
Riboflavin
is very
important in
the
regulatory
function of
the hormones
involved in
carbohydrate
metabolism.
It is
classified
as a
low-energy
package.
40mg to 80mg
given daily
by needle
I.M. 25 mg.
before meals
and bed
time.
7) Vitamin E
as d-alpha
Tocopherol
acetate of
d-alpha
Tocopherol
acid
succinate.
The latter
is more
practical
since it is
a pure form.
Complex
biochemical
changes in
the muscle
tissue in
chrome
vitamin E
deficiency
are followed
by
histalogical
lesions
characteristic
of muscular
dystrophy.
Deficiency
has also
been shown
to produce
demyelinization
and
distortion
of the axon
pattern in
the spinal
cord, giving
rise to
hypalgesia
and
progressive
paresis.
Fatal
massive
liver
necrosis
occurs in
animals
maintained
on diets low
in vitamin E
and
sulfur-containing
amino acids.
800
international
units before
meals and
bedtime must
be adhered
to in this
treatment.
Please
continue to
page -2
Multiple
sclerosis
treatment by
vitamins.
Multiple
sclerosis
triggered by
Celica is
fully
reversible
with diet.
Multiple
sclerosis
aspartame
Multiple
sclerosis
alternative
guide
