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What are polymyositis and dermatomyositis? 
- Polymyositis
(pronounced pah-lee-my-o-site-iss) is a disease that
causes muscles to be weak. After a person has had
polymyositis for a long time his or her muscles can
get smaller.
- Polymyositis can
affect the muscles in any part of the body. It can
also affect the lungs and the heart.
- It is called
dermatomyositis (pronounced
der-ma-toe-my-o-site-iss) when the skin is also
affected. It can cause skin rashes all over the
body.
- Both polymyositis
and dermatomyositis are chronic autoimmune diseases. This
means that they can last a very long time and they
come in attacks like waves in the sea..
- With both forms of
the disease, there may be times when the symptoms
are stronger (active periods) and then periods when
the symptoms lessen (remissions).
How common are polymyositis and dermatomyositis? 
- They affect 15,000
(1 in 2,000) .
- Women are affected
by polymyositis and dermatomyositis twice as often
as men.
- These diseases occur
most often in children between the ages of 5 and 15
and in adults between the ages of 50 and 70.
Polymyositis and dermatomyositis can occur
at any age but are most common in children and adults
over age 50. More adults than children get these
diseases.
One to five new cases per 100,000 are seen
each year. Women are affected by polymyositis and
dermatomyositis twice as often as men.
What are the warning signs of polymyositis and
dermatomyositis? 
- The main warning
sign is muscle weakness. Usually the first muscles
affected are in the hips and thighs, though any
other muscle in the body can be affected.
- It may be
hard to climb stairs, get dressed or get out of bed.
- Pain in the joints
between bones. However, the joints are usually not
warm or swollen, as with some other forms of
arthritis.
- Deep red (almost
purple) rash, usually on the face, scalp, neck and
chest. However, the rash can appear on any part of
the body.
- Coughing and
shortness of breath.
· It may also be hard to swallow.
Muscle weakness and pain
Usually, the main symptom of polymyositis is muscle
weakness. At the onset of the disease it generally
affects the thighs and hips. If you have polymyositis,
you may have difficulty climbing stairs, getting off
buses with high steps or rising from low surfaces. The
distance you are able to walk may eventually be limited
because your muscles get too tired.
If your shoulders are
involved, you may have trouble getting dressed, combing
your hair or lifting heavy objects. If polymyositis
affects your neck, chest and abdomen
muscles it may be
hard to lift your head from a pillow or get out of bed. Polymyositis can also cause you to have trouble
swallowing or talking, though these are less
common
results of the disease.
At the start of the disease your muscles may feel sore
and tender. Many people do not experience muscle pain;
it occurs particularly in people with rapidly
progressing disease.
The muscle pain and tenderness
usually goes away with treatment. After having the
disease for a long period of time you may lose muscle
bulk overall and the affected muscles
may appear thin
and ‘wasted.’
Skin rash
When a skin rash accompanies polymyositis, the term
dermatomyositis is used to describe the disease. If you
have dermatomyositis you will have muscle weakness and
will

develop a rash, most often on your face, scalp,
neck and chest. The rash can also appear on your hands
and fingers (often the knuckles), elbows, knees, ankles,
upper arms and thighs.
The rash is often deep red in colour (almost purple) and in some areas may be slightly
raised.
Joint pain
Joint pain commonly occurs during periods when the
disease is active, but the joints are not usually warm
or swollen, as often happens with other forms of
arthritis.
Lung involvement
Polymyositis and dermatomyositis can cause weakness
of the muscles required for breathing. They may also
cause fibrosis (build up of excessive fibrous tissue) of
the lungs.
If you have one of the diseases and your
lungs are involved you may experience coughing and
shortness of breath.
Heart involvement
In rare cases myocarditis (inflammation of the
muscular walls of the heart) and congestive heart
failure (heart disease accompanied by breathlessness and
excessive
retention of sodium and water) can occur as a
result of polymyositis or dermatomyositis.
Calcium Deposits
Calcification (pronounced cal-si-fi-kay-shun) is
hardening of skin and muscles as a result of calcium
salt deposits. Calcification doesn’t often occur in
adults with the disease,
but children with dermatomyositis may develop calcium deposits years after
the disease starts. The deposits generally develop in
the shoulder, pelvis, hip,
calf and thigh and may
severely limit motion. The masses that develop under the
skin can rupture and the calcium salts may drain.
Another physical finding in
dermatomyositis is the "machinist hands" with
cracking and fissuring of the distal digital
skin of the fingerpads.

What causes polymyositis and dermatomyositis? 
- With polymyositis
and dermatomyositis, the body’s immune system makes
a malfunction with these
diseases the immune system attacks healthy tissues.
- What triggers this process is unknown.
Polymyositis and dermatomyositis are
autoimmune diseases. This means that they begin with
the immune system (which normally protects the body from
germs, viruses, and bacteria)
malfunctioning. It
generates antibodies that attack healthy tissue in
different parts of the body. The cause of polymyositis
and dermatomyositis is unknown, though researchers
suspect
that environmental factors (such as viral
infections) may play a role, as may genetic factors
(meaning risk of getting the diseases may be inherited).
What can you do about polymyositis and
dermatomyositis?

- If your doctor thinks you have polymyositis or
dermatomyositis, he or she may refer you to a
rheumatologist (pronounced room-a-tol-o-jist)
- A rheumatologist is a doctor who has received
special training in the diagnosis and treatment of
problems with muscles, joints and bones.
- Your doctor may order certain laboratory tests.
He or she might perform a test called an EMG. This
test measures the electric current in your muscles.
- He or she might also cut away a very small piece of
muscle to be tested in a laboratory.
- There is no cure for polymyositis or
dermatomyositis, but there are things you can do to
manage the disease.
- Learn as much as you can about this disease.
Speaking with people who are specialists in
arthritis care can provide you with the information
you need.
There is no cure for polymyositis and
dermatomyositis. The goal of treatment is to help in the
management of symptoms. Establishing the correct
diagnosis early is important because
something can be
done to manage most forms of arthritis.
To be able to diagnose
whether you have polymyositis or dermatomyositis, your
doctor will perform a physical examination and probably
order laboratory tests, such as blood tests.
One test,
called a biopsy, involves cutting away a very small
segment of muscle tissue for analysis. Your doctor may
also perform a test called an EMG. With this test
electrodes are
taped to your skin and the electric
currents running through your muscles are recorded. This
shows whether your muscles are working properly.
A test called an MRI
(magnetic resonance imaging) may also be done. This
test is somewhat like an X-ray, in that it creates a
picture of the inside of your body. X-rays are only
used for
seeing bones though, and with an MRI a picture
can also be taken of your muscles.
If you are diagnosed with
polymyositis or dermatomyositis your active involvement
in developing your prescribed treatment plan is
essential.
- In most cases, oral cortisone is given to treat
polymyositis and dermatomyositis. Cortisone is a
steroid that reduces inflammation and can control
your immune system.
Cortisone is a steroid that reduces
inflammation and swelling and that can influence
regulation of the immune system. It is a hormone
naturally produced by the body.
Corticosteroids are
man-made drugs that closely resemble cortisone.
The most common form of
corticosteroid is called prednisone, taken in pill form.
Prednisone use needs to be carefully monitored because
of its many side effects,
and the drug must never be
stopped abruptly. Some of the side effects from
long-term use include cataracts, high blood pressure,
sleep problems, muscle loss,
bruising, thinning of the
bones (osteoporosis), weight gain and increased risk of
infections. The goal with this and most drugs is to
find the lowest effective dose
that will avoid as many
of the side effects as possible.
- People with polymyositis and dermatomyositis are
also often given disease modifying anti-rheumatic
drugs (DMARDs). DMARDs try to stop the disease from
getting worse.
- They can take about two to six
months before they make a difference.
ANTI-INFLAMMATORY medicine target the immune
system and the processes causing the symptoms, but do
not reverse permanent damage. The most common of them
are gold salts,
methotrexate, sulfasalazine,
hydroxychloroquinine, chloroquinine and azathioprine.
A are usually given in addition to other
medications. They usually take a few months to make a
difference
in the inflammation. Side effects may
include mouth sores, diarrhea and nausea. More serious
side effects, monitored through regular blood and urine
tests, include liver damage,
and excessive lowering of
the white blood cell count (increasing susceptibility to
certain infections) and platelet count (affecting blood
clotting).
- Gamma globulin may also be given. Gamma
globulin is made up of protein from human blood. It
is given through a tube inserted into the skin.
Intravenous gamma globulin
infusion has been used with some success in children
with polymyositis and dermatomyositis, and in some
adults with severe dermatomyositis.
If IVIg is given early it can slow the
disease process. The research at Nanotech Lahore
has shown that much lower dose of IVIg can be
used if the drug is given subcutaneous. Some
research
for IVIg sublingual doses is also being done.
The study is slowed due to excessive increase in
IVIg price.
Nanotech is concentrating their efforts
at lowering the treatment cost by alternatives
such as antibiotics, anti inflammatory fatty
acids and anti infective colloid solutions of
silver.
- If you have
polymyositis or dermatomyositis you should rest when
the disease is active.
- When the disease is
under control, exercise will help keep your muscles
from becoming too weak.
- The key is to strike
a balance between too much activity (which can
strain and tire muscles), and too little activity
(which can increase pain and stiffness and lead to
further weakness).
- There are three
types of exercises:
- Range of motion
exercises reduce stiffness and help keep your
joints moving. A range of motion exercise for
your shoulder would be to move your arm in a
large circle.
- Strengthening
exercises maintain or increase muscle strength
- Endurance
exercises strengthen your heart and give you
energy. These exercises include walking,
swimming and cycling.
- Your doctor can help
you find the exercise that best meets your needs.
- If you exercise
outdoors be sure to wear sunscreen. If you have
dermatomyositis, sunshine can make your skin rashes
worse.
Rest is generally
recommended during periods of active disease. Exercise
should be done when symptoms are under control to keep
muscles from becoming too weak.
Always consult your
doctor before beginning an exercise program. He or she
may also be able to refer you to a physical therapist
who can advise you of the forms of
exercise that are
likely to be helpful, and those that could be harmful.
If the disease has impaired your breathing, your
therapist can instruct you in breathing exercises.
Outcomes
Many people with
polymyositis and dermatomyositis respond well to
treatment. Some people only have a single attack of the
disease and are able to stop taking medications after
about a year.
Other people have
recurrent attacks or active periods of the disease that
respond to medication. These people are often given
regular low doses of medication to keep the disease
under control. While it is less common, some people
experience chronically active polymyositis or
dermatomyositis and must receive continuous
immunosuppressive treatments.
Infections, such as
pneumonia, can add to the severity of the disease.
Early diagnosis and
treatment, prompt treatment of infections and careful
monitoring of medications may reduce the severity of
complications and improve outcomes.
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