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Friday, 27
October,
2000, 02:04
GMT 03:04 UK
Hope
of
Parkinson's
'cure'
Parkiinson's
causes
shaking
and
muscle
stiffness
Scientists
have
successfully
reversed
the
spread
of
Parkinson's
disease
in
monkeys.
The
results
have
raised
hopes
that
scientists
could be
close to
stopping
the
disease
in
humans.
Researchers
from the
US and
Switzerland
used
gene
therapy
techniques
to
reverse
damage
in the
brains
of
monkeys
caused
by
Parkinson's.
They
used a
special
virus to
boost
nutrients
in the
brain.
These
nutrients
increase
the
production
of
dopamine.
Dopamine
sends
signals
in the
brain to
help
individuals
move
smoothly
and
normally.
The loss
of
dopamine
has been
linked
to the
symptoms
of
associated
with
Parkinson's.
Parkinson's
is a
brain
disease
and
causes
severe
difficulty
in
performing
movements
including
walking,
talking,
swallowing
and
smiling.
This
causes
sufferers
to shake
and
experience
muscle
stiffness.
Each
person
with
Parkinson's
is
affected
differently
and to
different
degrees.
Their
ability
to
perform
movements
may vary
from one
day to
the
next.
Sufferers
eventually
die from
secondary
complications
such as
pneumonia,
urinary
tract
infection,
pressure
sores,
septicaemia
and
stroke.
The
condition
is
treated
with
drugs
and
there is
no cure.
It
affects
around
120,000
people
in the
UK.
It
usually
strikes
people
between
the ages
of 50
and 60
although
it can
also
affect
younger
people.
Latest
research
This
latest
research
was
carried
out on
two
groups
of
monkeys.
The
first
group
involved
eight
older
monkeys
with
early
Parkinson's
disease.
The
second
included
younger
monkeys
with no
signs of
the
condition.
The
first
group
received
six
injections
of the
special
virus
called
lenti-GDNF
to boost
nutrients
in their
brain.
After
three
months
the
level of
dopamine
in their
brains
had
dramatically
increased
and were
similar
to those
found in
younger
monkeys.
The
second
group
were
injected
with a
chemical
to cause
Parkinson's
disease.
They
developed
the
condition
but this
was
reversed
once
they
received
lenti-GDNF.
Dr
Jeffrey
Kordower,
from
Rush
Presbyterian
St
Luke's
Medical
Centre
and one
of those
involved
in the
study,
said:
"By
giving
GDNF, we
can
stimulate
dopamine
production
and
prevent
both the
structural
and
functional
consequences
of cell
degeneration
that are
characteristic
of
Parkinson's
disease."
The
scientist
are
hoping
to use
this
special
virus on
humans
in
clinical
trials
within
five
years.
The
virus
was
developed
by
researchers
at the
Lausanne
University
in
Switzerland.
Dr
Kordower
added:
"This
study
suggests
a new
approach
to
forestall
disease
progression
in newly
diagnosed
Parkinson's
disease
patients."
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Principles of Effective Treatment
- No single treatment is
appropriate for all individuals.
Matching treatment settings,
interventions, and services to each
individual's particular problems and
needs is critical to his or her ultimate
success in returning to productive
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and society.
- Treatment needs to be readily
available. Because individuals who
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about entering treatment, taking
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ready for treatment is crucial.
Potential treatment applicants can be
lost if treatment is not immediately
available or is not readily accessible.
- Effective treatment attends to
multiple needs of the individual, not
just his or her drug use. To be
effective, treatment must address the
individual's drug use and any associated
medical, psychological, social,
vocational, and legal problems.
- An individual's treatment and
services plan must be assessed
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ensure that the plan meets the person's
changing needs. A patient may
require varying combinations of services
and treatment components during the
course of treatment and recovery. In
addition to counseling or psychotherapy,
a patient at times may require
medication, other medical services,
family therapy, parenting instruction,
vocational rehabilitation, and social
and legal services. It is critical that
the treatment approach be appropriate to
the individual's age, gender, ethnicity,
and culture.
- Remaining in treatment for an
adequate period of time is critical for
treatment effectiveness. The
appropriate duration for an individual
depends on his or her problems and needs
(see pages 11-49). Research indicates
that for most patients, the threshold of
significant improvement is reached at
about 3 months in treatment. After this
threshold is reached, additional
treatment can produce further progress
toward recovery. Because people often
leave treatment prematurely, programs
should include strategies to engage and
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- Counseling (individual and/or
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are critical components of effective
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build skills to resist drug use, replace
drug-using activities with constructive
and rewarding nondrug-using activities,
and improve problem-solving abilities.
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interpersonal relationships and the
individual's ability to function in the
family and community.
- Medications are an important
element of treatment for many patients,
especially when combined with counseling
and other behavioral therapies.
Methadone and levo-alpha-acetylmethadol
(LAAM) are very effective in helping
individuals addicted to heroin or other
opiates stabilize their lives and reduce
their illicit drug use. Naltrexone is
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opiate addicts and some patients with
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of treatment. For patients with mental
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and medications can be critically
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- Addicted or drug-abusing
individuals with coexisting mental
disorders should have both disorders
treated in an integrated way.
Because addictive disorders and mental
disorders often occur in the same
individual, patients presenting for
either condition should be assessed and
treated for the co-occurrence of the
other type of disorder.
- Medical detoxification is only
the first stage of addiction treatment
and by itself does little to change
long-term drug use. Medical
detoxification safely manages the acute
physical symptoms of withdrawal
associated with stopping drug use. While
detoxification alone is rarely
sufficient to help addicts achieve
long-term abstinence, for some
individuals it is a strongly indicated
precursor to effective drug addiction
treatment
- Treatment does not need to be
voluntary to be effective. Strong
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family, employment setting, or criminal
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occur during treatment. The objective
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help the patient withstand urges to use
drugs. Such monitoring also can provide
early evidence of drug use so that the
individual's treatment plan can be
adjusted. Feedback to patients who test
positive for illicit drug use is an
important element of monitoring.
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assessment for HIV/AIDS, hepatitis B and
C, tuberculosis and other infectious
diseases, and counseling to help
patients modify or change behaviors that
place themselves or others at risk of
infection. Counseling can help
patients avoid high-risk behavior.
Counseling also can help people who are
already infected manage their illness.
- Recovery from drug addiction can
be a long-term process and frequently
requires multiple episodes of treatment.
As with other chronic illnesses,
relapses to drug use can occur during or
after successful treatment episodes.
Addicted individuals may require
prolonged treatment and multiple
episodes of treatment to achieve
long-term abstinence and fully restored
functioning. Participation in self-help
support programs during and following
treatment often is helpful in
maintaining abstinence.
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