Mad Cow Disease

Autoimmune Mad Cow

	Many Epilepsy syndromes are autoimmune and easily and permanently treatable please read our e-book . Prof. Alan EBRINGER,B.Sc, MD, FRCP, FRACP, FRCPath, HonFRSHKing�s College LondonYour Royal Highnesses, Mr. Chairman, Ladies and Gentlemen.I would like to thank The Royal Society for the Promotion of Health for the great honour it has bestowed on me in awarding the Donaldson Gold Medal to me for the work from our group,on �Bovine Spongiform Encephalopathy or BSE or morecommonly known as MAD COW DISEASE. This work is a credit to the outstanding group of research workers in our Unit, especially Dr. Clyde WILSON , who recently was elected a Member of the �Royal College of Pahologists� rather than to anything I may have done personally.I graduated in Medicine from the University of Melbourne way back in 1962, obtained a Travelling Scholarship from the �Royal Australasian College of Physicians� to come to the U.K. and I have been working in the University of London since 1970.Over the last thirty years, our group has been studying the autoimmune diseases, ANKYLOSING SPONDYLITIS, a chronic condition characterized by backache and also another arthritic disease RHEUMATOID ARTHRITIS. We have found thatANKYLOSING SPONDYLITIS is triggered by the bowel microbe KLEBSIELLLAand RHEUMATOID ARTHRITIS is produced following a urinary tract infection by the microbe PROTEUS.Prof. Feltkamp from Amsterdam in the Netherlands, asked us to cooperate in a joint study, which showed that Dutch patients with ANKYLOSING SPONDYLITIS have antibodies to KLEBSIELLA and Dutch patients with RHEUMATOID ARTHRITIS have antibodies to PROTEUS, as do English patients. These results have beenpublished.In AUTOIMMUNE DISEASES patients have antibodies which attack their own organs and these are called AUTOANTIBODIES. Our model for studying autoimmunediseases was RHEUMATIC FEVER, which is caused by the microbeSTREPTOCOCCUS, which infects the tonsils and has components which resemble the human heart.Following a STREPTOCOCCAL TONSILLITIS antibodies are produced which attack not only the microbe itself but also the human heart and cause RHEUMATIC FEVER.Thus MOLECULAR MIMICRY or similarity between a microbe and a target organ produces an AUTOIMMUNE DISEASE.RHEUMATIC FEVER is no longer a problem in the Western world becauseSTREPTOCOCCAL TONSILLITIS responds to antibiotics but in countries of theThird World where access to such drugs is financially prohibitive, the disease remains a serious problem. -------------------------------------------------------------------------------- We have used this concept of MOLECULAR MIMICRY to identify the trigger factors in RHEUMATOI ARTHRITIS and ANKYLOSING SPONDYLITIS.Over the last seven years, our group has been studying �bovine spongiformencephalopathy� (BSE), also known as MAD COW DISEASE. A computer analysis showed that the soil and skin microbe ACINETOBACTER has components whichresemble brain tissues.We approached MAFF (Ministry of Agriculture, Fisheries and Food) with the idea that we had an alternative theory , an AUTOIMMUNE THEORY, to the PRIONHYPOTHESIS, which could explain the origin of BSE. Despite a few objections from some quarters, some funds were made available and access given to BSE material.A study of BSE affected cattle showed that they have elevated levels of antibodies to the soil bacterium ACINETOBACTER, a microbe which has components resembling brain tissues and to a lesser extent to the related microbe PSEUDOMONAS..So far we have studied 508 animals; 218 with BSE and compared them to 290 controls. These results are specific since the BSE animals do not show antibody elevations to five other microbes: KLEBSIELLA, PROTEUS, SERRATIA, E.COLI, BACILLUS and AGROBACTERIUM.The elevated levels of antibodies to ACINETOBACTER found in BSE cattle lends itself to the development for an ANTE-MORTEM TEST for �BSE�,It has been proposed that BSE is caused by exposure to ACINETOBACTER fragments, found in the �meat-and-bonemeal� flour meal fed to cattle.The hypothesis is that antibodies against ACINETOBACTER, attack the brain and cause MAD COW DISEASE.The first time that a BSE cow was observed, it was found to be standing on its forelegs but falling down by its hindquarters and in this it resembles MULTIPLE SCLEROSIS patients who have a greater incidence of lower limb paralysis.Patients with MULTIPLE SCLEROSIS were also found to have antibodies toACINETOBACTER and to the related microbe PSEUDOMONAS.Over 50% of patients with MULTIPLE SCLEROSIS suffer from SINUSITIS and thus could have become infected by the saprophytic microbe ACINETOBACTER.The general hypothesis is proposed that BSE is MULTIPLE SCLEROSIS in cows and therefore it is an autoimmune disease which CANNOT BE TRANSMITTED BY THE CONSUMPTION OF �BSE� AFFECTED MEAT.If this theory can be confirmed then the following conclusions arise:(1)Consumption of meat is safe and has always been safe. -------------------------------------------------------------------------------- (2)Culling of cattle was unnecessary.(3)There will be no epidemic of CJD.(4)An ante-mortem test for detecting BSE in live cattle is feasible. Clearly the autoimmune theory of BSE requires further investigations but two months ago, DEFRA withdrew research funds for such studies.We are currently cooperating with our Dutch colleagues in studying patients withMULTIPLE SCLEROSIS.We hope that such Anglo-Dutch studies will continue in the future and serve not only international cooperation but also the aims and mission of the Royal Society for the Promotion of Health.Thank you for your attention.	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