Alzheimers  & IVIg                      

100 Million people will get Alzheimer's, you do not want to spend time in a nursing home get our E-book to prevent Alzheimers. Memory disorders are the most common symptom world wide. First book to provide reversal of all memory disorders. We have tried and reversed patients who had Alzheimer's.

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Alzheimers is caused by multiple factors and is not a single disease. However the disease that we commonly call Alzheimers is essentially autoimmune. By reducing inflammation the disease reverses. The following pages will show you how some drugs like IVIg help reverse the disease. If you are having memory problems simply drinking more water will improve memory. Alcohol in any form has detrimental effects on memory as a  glass of beer will get rid of a million brain cells. Please read the curry link on the left to start protecting your brain from Alzheimer's. Omega-3 fatty acids also help Alzheimer's and so will the anti-inflammatory diet described on our diet page.

FRIDAY, April 22 (HealthDay News) -- Regular infusions of plasma   derived antibodies appear to reduce levels of Alzheimer's disease-causing brain plaques while improving patients' thinking ability, researchers report.

Buildup of beta-amyloid protein plaques in the brain is a hallmark of Alzheimer's and toxicity related to this buildup is thought to be a major cause of the disease, for which there is currently no effective treatment.

In this phase I clinical study, conducted by a team from New York-Presbyterian Hospital/Weill Cornell Medical Center, researchers gave patients with mild to moderate Alzheimer's periodic infusions of a targeted antibody, called immunoglobulin (IVIg). The antibody makes its way to the brain where it targets beta-amyloid for removal.

The study included eight Alzheimer's patients treated with IVIg. After six months of treatment, seven of the patients underwent cognitive testing. The tests showed that cognitive function stopped declining in all seven patients and had actually improved in six of the seven patients.

"If these results are confirmed in larger, controlled trials, we might have a safe Alzheimer's treatment capable of clearing the amyloid protein away," senior researcher Dr. Marc E. Weksler said in a prepared statement.

The study was presented at the recent annual meeting of the American Academy of Neurology in Miami.

The researchers emphasize that it's too soon to describe IVIg as anything more than promising, and they do not recommend that doctors treat Alzheimer's patients with IVIg at this point in time. Preparations are already underway for a larger, controlled Phase II clinical trial of IVIg, the researchers said.

IVIg is an antibody product derived from human plasma. The U.S. Food and Drug Administration has long approved the use of IVIg to treat other conditions, but not Alzheimer's.

It has been well known that Alzheimer's causes beta amyloid deposits in the brain. Antibodies against beta amyloid can be measured in C.S.F. these antibodies are reduces in patients who go on to develop Alzheimer's.  IVIg contains these antibodies so it is no miracle that it helps stop the disease in its track.

 

What is IVIg? IVIg stands for IntraVenous Immunoglobulin. It is a product of human blood that is derived from the plasma of thousands of healthy volunteers. IVIg contains antibodies, which are the proteins that help protect the body against disease.

Why is IVIg being studied as a treatment for Alzheimer's? It was recently discovered that IVIg contains antibodies that bind to beta amyloid (A¤). A¤ is a protein that many scientists believe is important in causing Alzheimer's. IVIg may help to promote the clearance of A¤ from the brain and block A¤'s toxic effects on brain cells.

Is IVIg a new treatment? IVIg was originally approved by the U.S. Food and Drug Administration for treating immune disorders and has been available for more than 30 years. IVIg is FDA-approved for the treatment of patients with primary immunodeficiencies, immune thrombocytopenic purpura (ITP), B-cell chronic lymphocyctic leukemia (CLL), Kawasaki syndrome, and immunodeficiency associated with pediatric HIV and bone marrow transplantation.

Neurologists also use IVIg in the treatment of multiple sclerosis and motor neuropathy, though IVIg is not approved for these conditions. It is--not currently approved to treat Alzheimer's disease, but is under study for that purpose.

How is IVIg treatment given? IVIg is administered by an infusion into a vein, a process that typically takes several hours. It is believed that infusions have to be carried out at least once or twice a month in Alzheimer's patients.

Is IVIg safe? Several hundred thousand persons have received IVIg over the years, and it is generally well-tolerated. There may be added risks to its use in elderly individuals with Alzheimer's, but many older persons have received IVIg without difficulty.

Because it is derived from human plasma, IVIg carries with it a very small risk of communicable diseases such as Hepatitis and HIV. However, in the United States there have been no documented cases of transmission of these diseases by IVIg over the past 10 years.

Other possible risks relating to use of IVIg include kidney failure, stroke, lung problems, heart failure, allergic reactions and other problems. The likelihood of these complications occurring can be reduced by screening out persons who have known risk factors and administering the IVIg in modified forms.

 

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