Memory
Disorders
and
Limbic
Encephalitis
"Palliating
delirium in patients with
cancer"
Limbic
Encephalitis Tied to Adult Onset
Epilepsy
Limbic encephalitis presenting
as delirium in a patient who
underwent bone-marrow transplant
for non-Hodgkin lymphomaCoronal
MRI shows high signal (white)
bilaterally in the temporal
lobes in the areas corresponding
to the hypocampal uncus. The
surrounding white matter shows
oedema (arrows). The CSF
examination confirmed diagnosis
of herpes 6 virus encephalitis.
The
limbic lobe is a complex set of
three C-shaped structures
containing both gray and white
matter. It lies deep within the
brain and includes portions of
all the lobes of the cerebral
hemispheres. A myriad of fiber
tracts connect the limbic lobe
with numerous deep nuclei and
the olfactory apparatus to form
the limbic system.
Phylogenetically, the limbic
system is one of the more
primitive parts of the brain. It
has a central role in memory,
learning, emotion,
neuroendocrine function, and
autonomic activities. Clinical
conditions involving the limbic
system include epilepsy,
congenital syndromes, dementias,
and various psychiatric
disorders.
By David Douglas
NEW YORK (Reuters Health) Oct
10 - Limbic encephalitis may
often be a precipitating event
in adult-onset temporal lobe
epilepsy, according to German
researchers.
Limbic encephalitis, lead
investigator Dr. Christian G.
Bien told Reuters Health, "is
protracted brain inflammation,
probably of autoimmune origin,
which is sometimes a corollary
of malignant diseases outside
the nervous system, but may also
occur without apparent cause."
In the September 18th issue
of Neurology, Dr. Bien of the
University of Bonn and
colleagues note that temporal
lobe epilepsy with hippocampal
sclerosis usually starts in
childhood or adolescence, but
can manifest in adulthood. "In
earlier times," added Dr. Bien,
"it could only be detected by
postmortem autopsies. Since the
early 1990s, hippocampal
sclerosis can be visualized by
brain MRI in vivo."
To characterize factors
associated with adult-onset
disease, the researchers
conducted a retrospective review
of data on 38 patients with
epilepsy onset at a median age
of 37.8 years.
Eleven had hippocampal
sclerosis due to events such as
head trauma and febrile
seizures, and seven were
classified as being of
idiopathic origin.
Nine had MRI findings typical
of limbic encephalitis, and
another eleven were deemed as
possibly having the condition.
Thus, say the investigators,
about half of the patients
showed evidence consistent with
an autoimmune process.
Subjects in these two
subgroups were significantly
more likely to have bilateral
abnormalities than were those
without such findings.
In an accompanying editorial,
Dr. Andrew G. Cole of
Massachusetts General Hospital
notes that the study has a
number of limitations, but
concludes that these results
"will trigger more aggressive
searches for immunomarkers in
patients with focal epilepsy of
unknown cause, whatever their
age."
Neurology
2007;69:1236-1244.
Get our memory reversal protocol works on most people. Covers
all common medical issues.
Disclaimer: This protocol has not been evaluated by FDA and for medical
problems its best you get treatment from a professional qualified person
Please continue to
page-2 to read about causes of memory disorders
Services
We will not evaluate a case unless a payment has been made by
paypal in Pakistan pay by Telenor easy pisa
"Palliating delirium in patients with cancer"
Limbic Encephalitis Tied to Adult Onset Epilepsy
Limbic encephalitis presenting
as delirium in a patient who
underwent bone-marrow transplant
for non-Hodgkin lymphomaCoronal
MRI shows high signal (white)
bilaterally in the temporal
lobes in the areas corresponding
to the hypocampal uncus. The
surrounding white matter shows
oedema (arrows). The CSF
examination confirmed diagnosis
of herpes 6 virus encephalitis.
The
limbic lobe is a complex set of
three C-shaped structures
containing both gray and white
matter. It lies deep within the
brain and includes portions of
all the lobes of the cerebral
hemispheres. A myriad of fiber
tracts connect the limbic lobe
with numerous deep nuclei and
the olfactory apparatus to form
the limbic system.
Phylogenetically, the limbic
system is one of the more
primitive parts of the brain. It
has a central role in memory,
learning, emotion,
neuroendocrine function, and
autonomic activities. Clinical
conditions involving the limbic
system include epilepsy,
congenital syndromes, dementias,
and various psychiatric
disorders.
By David Douglas
NEW YORK (Reuters Health) Oct 10 - Limbic encephalitis may often be a precipitating event in adult-onset temporal lobe epilepsy, according to German researchers.
Limbic encephalitis, lead investigator Dr. Christian G. Bien told Reuters Health, "is protracted brain inflammation, probably of autoimmune origin, which is sometimes a corollary of malignant diseases outside the nervous system, but may also occur without apparent cause."
In the September 18th issue of Neurology, Dr. Bien of the University of Bonn and colleagues note that temporal lobe epilepsy with hippocampal sclerosis usually starts in childhood or adolescence, but can manifest in adulthood. "In earlier times," added Dr. Bien, "it could only be detected by postmortem autopsies. Since the early 1990s, hippocampal sclerosis can be visualized by brain MRI in vivo."
To characterize factors associated with adult-onset disease, the researchers conducted a retrospective review of data on 38 patients with epilepsy onset at a median age of 37.8 years.
Eleven had hippocampal sclerosis due to events such as head trauma and febrile seizures, and seven were classified as being of idiopathic origin.
Nine had MRI findings typical of limbic encephalitis, and another eleven were deemed as possibly having the condition. Thus, say the investigators, about half of the patients showed evidence consistent with an autoimmune process.
Subjects in these two subgroups were significantly more likely to have bilateral abnormalities than were those without such findings.
In an accompanying editorial, Dr. Andrew G. Cole of Massachusetts General Hospital notes that the study has a number of limitations, but concludes that these results "will trigger more aggressive searches for immunomarkers in patients with focal epilepsy of unknown cause, whatever their age."
Neurology 2007;69:1236-1244.
Get our memory reversal protocol works on most people. Covers all common medical issues.
Disclaimer: This protocol has not been evaluated by FDA and for medical problems its best you get treatment from a professional qualified person
Please continue to page-2 to read about causes of memory disorders
|