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DIET Your diet has to be lower in calories if you want to live longer. There is no question about it You have to burn all the food you take in. If you take in more food than you need, there is an excess of calories to burn up which produces free radicals, and all the biological systems are then overtaxed to overcome the free radicals. Whenever you overtax the body, the albumin levels go down and the immunoglobulins go up. When you reduce calories, the albumin level goes up. The albumin is the transporter protein in the blood which carries all the nutrients and hormones. The albumin levels are just as important as the HDL, the triglycerides and the cholesterol. The average albumin levels range between 35 and 50 g/L of blood. The closer it is to 50, the healthier you are. The albumin levels will predict longevity and survival in prostate cancer more accurately than the extent and duration of the disease. So lowering the calories increases longevity. Everybody understands that. Research done at U.C.L.A. has proven it over and over in animals. In rats, they can increase the maximum life span sometimes by 50%.

EXERCISE Exercise is probably the single most powerful longevity drug available. Exercise increases the albumin level, increases the lean muscle mass and decreases the fat. Exercise maintains the maximum oxygen retention. Like a low calorie diet, it takes discipline, focus and determination to keep it up, but it works.

HORMONE REPLACEMENT: DHEA AND PREGNENOLONE The two hormones, DHEA and pregnenolone (precursors of progesterone, estrogen and testosterone), are produced in the adrenal gland and also in the brain. We can replace them with hormonal supplements. Low levels of DHEA and pregnenolone are associated with disease profiles and age-related characteristics more than any other hormones. If you look at DHEA blood levels in populations of 60 to 80 years, those who are in nursing homes are in the lower 25% of DHEA blood levels. Those in the upper 25% are never in nursing homes. They are caring for themselves. So you can stratify who is in nursing homes based upon the DHEA blood levels. Research has shown that when you replace DHEA in men and women, men had a 79% increase in the sense of well-being, and women had a 67% increase. When you increase the sense of well being in a 75 year old, then that person will groom and take care of himself and be more active in society, so the quality of life of that individual will improve. Low DHEA levels are more predictive of a heart attack than is a high cholesterol level. Those with low DHEA levels are more prone to heart attacks, cancer and other problems. What are the side effects of DHEA supplements? There aren't any that I know of. Most research on DHEA was done back in the 40's when it was used as a treatment for arthritis. Pregnenolone was used in the same way. In the U.S. both DHEA and Pregnenolone are available over the counter, but they are only available by prescription in Canada. I have been prescribing DHEA as a physician for about 12 years. We test blood levels before and after, and find that the supplements increase DHEA blood levels. So this type of hormone replacement is a rational definable precise strategy for longevity which can be utilized. It is not dangerous. It is simply physiological supplementation.


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