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Sunday, May 01, 2005 Commentary |
Controlled-Release Alpha-Lipoic Acid Introduced for Diabetics (press
release)
The First and Only Proprietary, Controlled-Release Formulation of
Alpha-Lipoic Acid Reduces Oxidative Stress Associated with Diabetes
by Antagonizing Excessive Free Radicals at the Cellular Level
Medical Research Institute (MRI), an innovator in nutraceutical
approaches for diabetes, today announced the availability of
Glucotize(TM), the only patented (three US patents awarded;
additional applications filed), controlled-release formulation of
the safe and effective antioxidant alpha-lipoic acid. Extensive
research and clinical experience have indicated that alpha-lipoic
acid is safe, well tolerated, and effective in providing symptomatic
relief of diabetic neuropathy. Most recently, results from a
collaborative study between groups from the Mayo Clinic and the
Russian Medical Academy reported that alpha-lipoic acid rapidly and
significantly reduced the frequency and severity of symptoms from
diabetic polyneuropathy (Ametov et al Diabetes Care 2003 26:770-6).
More recently, alpha-lipoic acid has been reported to improve
whole-body glucose metabolism and insulin sensitivity in individuals
with type 2 diabetes, which if confirmed in larger studies, could
help in the prevention and treatment of type 2 diabetes along with
other conditions associated with impaired glucose metabolism.
Intravenous infusions of ALA have been used with outstanding results
by physicians in Germany for more than 25 years to treat neuropathy,
a common diabetic complication, and one that causes significant pain
and discomfort.
While other manufacturers offer alpha-lipoic acid, it is not
controlled release, a limitation that means alpha-lipoic acid is
eliminated from the body very quickly -- in as little as 30 minutes
-- significantly hampering its efficacy. MRI's Glucotize(TM) is a
unique oral formulation whose controlled-release formulation remains
in the body for hours rather than minutes.
"It's well known that alpha-lipoic acid helps protect mitochondria
-- the 'power plant' found in each cell -- from being damaged by
toxic byproducts created when those mitochondria are deluged with
too much glucose or fatty acids," said Dr. Joseph L. Evans, MRI's
vice president of Research and Development and Chief Scientific
Officer. "We believe that there is a compelling scientific rationale
that supports the use of alpha-lipoic acid to reduce oxidative
stress (too many free radicals) in individuals with diabetes, a
strategy that has been shown to offer symptomatic relief for
diabetic peripheral neuropathy. MRI's approach has been to overcome
the rapid elimination of alpha-lipoic acid by developing a
controlled release formulation, which maintains an effective level
in the body for a longer time."
"Alpha-lipoic acid has long been recognized for its beneficial
impact on diabetic neuropathy," said Dr. Ira D. Goldfine, director,
Division of Diabetes & Endocrine Research, Mount Zion Medical
Center, University of California San Francisco. "However, the
current oral formulations typically remain in the blood only a very
short time, requiring either multiple daily doses or intravenous
infusions. While more clinical studies are needed with
controlled-release oral formulations of alpha-lipoic acid, it is
clear that such preparations should be very helpful for diabetics
suffering from complications such as neuropathy."
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